Do adjunct TB tests , when combined with Xpert MTB / RIF , improve accuracy and the cost of diagnosis in a resource - poor setting ?
نویسندگان
چکیده
Grant Theron, Anil Pooran, Jonny Peter, Richard van Zyl-Smit, Hridesh Kumar Mishra, Richard Meldau, Greg Calligaro, Brian Allwood, Surendra Kumar Sharma, Rod Dawson, Keertan Dheda 3* Lung Infection and Immunity Unit, Division of Pulmonology & UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa. Department of Medicine, All India Institute of Medical Sciences, New Delhi, India. Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
منابع مشابه
Do adjunct tuberculosis tests, when combined with Xpert MTB/RIF, improve accuracy and the cost of diagnosis in a resource-poor setting?
Information regarding the utility of adjunct diagnostic tests in combination with Xpert MTB/RIF (Cepheid, Sunnyvale, CA, USA) is limited. We hypothesised adjunct tests could enhance accuracy and/or reduce the cost of tuberculosis (TB) diagnosis prior to MTB/RIF testing, and rule-in or rule-out TB in MTB/RIF-negative individuals. We assessed the accuracy and/or laboratory-associated cost of diag...
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Performance of the Xpert MTB/RIF assay, designed to simultaneously detect Mycobacterium tuberculosis complex (MTBC) and rifampin (RIF) resistance, has been well documented in low-resource settings with high TB-incidence. However, few studies have assessed its accuracy in low TB incidence settings. We evaluated the performance of Xpert MTB/RIF using clinical sputum specimens routinely collected ...
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BACKGROUND High costs are a limitation to scaling up the Xpert MTB/RIF assay (Xpert) for the diagnosis of tuberculosis in resource-constrained settings. A triaging strategy in which a sensitive but not necessarily highly specific rapid test is used to select patients for Xpert may result in a more affordable diagnostic algorithm. To inform the selection and development of particular diagnostics...
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